About 1 result found for searched term "YS-370 " (0.116 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29668 | YS-370 | P-glycoprotein |
| YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. | ||
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