About 13 results found for searched term "Thioredoxin reductase" (0.134 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M50316 | Thioredoxin reductase | Enzymes & Coenzymes |
| Thioredoxin reductase (TrxR) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M51238 | Thioredoxin reductase peptide | Others |
| Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. | ||
| M3178 | Auranofin | Anti-infection |
| SKF-39162 | ||
| Auranofin is an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). | ||
| M3356 | Busulfan | DNA Alkylator/Crosslinker |
| Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan also inhibits thioredoxin reductase. | ||
| M6592 | Chaetocin | Histone Methyltransferase |
| Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. | ||
| M9623 | APR-246 (Eprenetapopt) | p53 |
| PRIMA-1MET; Eprenetapopt | ||
| APR-246 (Eprenetapopt) is the first-in-class small molecule to restore wild-type p53 function in TP53 mutant cells. APR-246 (Eprenetapopt) also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells. | ||
| M13783 | Fast-TRFS | Fluorescent Dye |
| Fast-TRFS is a selective and superfast fluorogenic probe of thioredoxin reductase (TrxR). Fast-TRFS can be used for imaging TrxR activity in live cells. | ||
| M14787 | TRFS-green | Others |
| TRFS-green is a highly selective off−on fluorescent probe for imaging thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. | ||
| M20739 | TRi-1 | Others |
| HUN20688, TXNRD1 inhibitor 1 | ||
| TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. TRi-1 exhibits anti-cancer activity while having little mitochondrial toxicity. | ||
| M27978 | Aurothiomalate sodium | PKC |
| Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity. | ||
| M28572 | TrxR inhibitor D9 | Apoptosis |
| TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo. | ||
| M28958 | Mito-TRFS | Fluorescent Dye |
| Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells. | ||
| M30159 | PMX464 | Others |
| AW 464 | ||
| PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells. | ||
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