About 1 result found for searched term "TVB-3166" (0.14 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8622 | TVB-3166 | FAS |
| TVB3166 | ||
| TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. | ||
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