THZ1 - Search Results | AbMole BioScience

About 7 results found for searched term "THZ1" (0.052 seconds)

Cat.No.	Name	Target
M5228	THZ1	CDK
	CDK7 inhibitor
	THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
M9779	THZ531	CDK
	THZ-531
	THZ531 is a covalent CDK12 and CDK13 inhibitor with IC50 values of 158 nM and 69 nM, respectively.
M10913	THZ1-R	CDK
	THZ1-R is a non-cysteine-reactive analogue of THZ1 with reduced activity against CDK7 inhibition. THZ1-R in combination with CDK7 Kd 142 nM.
M13617	THZ1 Hydrochloride	CDK
	THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.
M21521	THZ-P1-2	PI5P4K
	THZ-P1-2 is a first-in-class, selective PI5P4K inhibitor with an IC50 of 190 nM for Pi5P4α.
M55216	TH-Z145	Antibiotic
	THZ145
	TH-Z145 is a lipophilic GGPPS inhibitor (GGPPS IC50 = 210 nM). TH-Z145 is a very lipophilic bisphosphonate that lacks the cationic center essential for FPPS inhibition and is thus a specific GGPPS inhibitor (FPPS IC50 >30 mM). TH-Z145 exhibited strong prophylactic effects in a pathogenic influenza model.
M55942	bio-THZ1	CDK
	bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7.