About 6 results found for searched term "TH588" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8899 | TH588 | MTH1 |
| TH588 is a first-in-class, potent, selective MTH1 (NUDT1) inhibitor with an IC50 value of 5 nM. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M11170 | NSC745885 | Apoptosis |
| NSC745885 is a potent anti-tumor reagent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent downregulator of EZH2 through the proteasome degradation pathway. NSC745885 offers the possibility of research on advanced bladder cancer and oral squamous cell carcinoma. | ||
| M30735 | Methylprednisolone aceponate | GCR |
| ZK 91588; MPA | ||
| Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders. | ||
| M41883 | BVFP | Neurotensin Receptor |
| BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. | ||
| M49592 | JAK3-IN-11 | JAK |
| JAK3-IN-11 , a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. | ||
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