About 12 results found for searched term "TAPI-0" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6215 | TAPI-0 | MMP |
| TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases. | ||
| M55908 | TAPI-0 | TNF Receptor |
| TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. | ||
| M2208 | Lomitapide | Others |
| AEGR-733, BMS-201038 | ||
| Lomitapide (AEGR-733, BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. | ||
| M3634 | TAPI-1 | Immunology/Inflammation |
| TAPI-1 is an ADAM17/TACE inhibitor that blocks shedding of cytokine receptors with IC50 value of 8.09 microM. | ||
| M4463 | Abametapir | MMP |
| HA-44; BRN 0123183; 5,5′-Dimethyl-2,2′-dipyridyl | ||
| Abametapir (HA-44, BRN 0123183) is an inhibitor of metalloproteinases critical for louse survival and egg development. | ||
| M5786 | Metyrapone | Metabolite/Endogenous Metabolite |
| Metapirone; Su-4885 | ||
| Metyrapone (Metapirone) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone (Metapirone) inhibits cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. | ||
| M6216 | TAPI-2 | MMP |
| TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. | ||
| M8932 | Eptapirone | 5-HT Receptor |
| F11440 | ||
| Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. | ||
| M10941 | Tapinarof | Aryl hydrocarbon Receptor |
| WBI-1001; Benvitimod; GSK2894512 | ||
| Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. | ||
| M27941 | AV-105 | Others |
| AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain. | ||
| M30492 | (R)-TAPI-2 | Others |
| (R)-TNF Protease Inhibitor 2 | ||
| (R)-TAPI-2 is the isomer of TAPI-2. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV. | ||
| M42567 | Motapizone | PDE |
| Motapizone (NAT 05-239) is a selective PDE3 inhibitor. | ||
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