About 14 results found for searched term "Src Inhibitor-1" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8160 | Src Inhibitor-1 | Src-bcr-Abl |
| Src Kinase Inhibitor 1; Src-l1 | ||
| Src interactivator -1 is a highly selective, ATP-competitive, two-site Src tyrosine kinase Inhibitor with IC50 values of 44 nM and 88 nM against Src and Lck, respectively. It also inhibits Csk and Yes. | ||
| M4843 | SU6656 | Src-bcr-Abl |
| SU-6656 | ||
| SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. | ||
| M5552 | Dasatinib HCl | Src-bcr-Abl |
| BMS 354825 hydrochloride | ||
| Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of ＜1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. | ||
| M9664 | TL02-59 | Src-bcr-Abl |
| TL0259 | ||
| TL02-59 is a selective, orally active Src-family kinase Fgr inhibitor with IC50 of 0.03 nM, it also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. | ||
| M9798 | 1NM-PP1 | Src-bcr-Abl |
| 1-NM-PP1; PP1 Analog II | ||
| 1NM-PP1 is a cell-permeable and potent Src family kinases inhibitor with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. | ||
| M10964 | TPX-0046 | RET |
| TPX-0046 is a novel RET/SRC inhibitor that is used against RET in Ba/F3 cell proliferation assaysG810R The average IC50 is 17 nM. | ||
| M14910 | A-770041 | Src-bcr-Abl |
| A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. | ||
| M14911 | CH6953755 | Src-bcr-Abl |
| CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo. | ||
| M28900 | CHMFL-ABL-053 | Src-bcr-Abl |
| CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively. | ||
| M29706 | DGY-06-116 | Src-bcr-Abl |
| DGY-06-116 is an irreversible covalent, selective Src inhibitor with an IC50 of 3nM. DGY-06-116 inhibits FGFR1 with an IC50 of 8340 nM. | ||
| M30952 | Lck inhibitor 2 | Src-bcr-Abl |
| Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). | ||
| M49688 | STAT3-SH2 domain inhibitor 1 | STAT |
| STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. | ||
| M50176 | Saracatinib difumarate | Src-bcr-Abl |
| AZD0530 difumarate | ||
| Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and it is selective for other tyrosine kinases. | ||
| M57215 | KB SRC 4 | Src-bcr-Abl |
| KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity. | ||
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