Squalene synthase-IN-1 - Search Results

About 5 results found for searched term "Squalene synthase-IN-1" (0.14 seconds)

Cat.No.	Name	Target
M42952	Squalene synthase-IN-1	Others
	Squalene synthase-IN-1 is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition.
M2800	KY02111	Others
	KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease.
M28612	BPH-652	Others
	BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation).
M28935	YM-53601	Farnesyl Transferase
	YM-53601 is a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation.
M28936	YM-53601 hydrochloride	Farnesyl Transferase
	YM-53601 hydrochloride is a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 hydrochloride inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. YM-53601 hydrochloride is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation.