About 1 result found for searched term "SKLB-163" (0.125 seconds)
Cat.No. | Name | Target |
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M55643 | SKLB-163 | Apoptosis |
SKLB163 | ||
SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK. SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell Apoptosis. |
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