About 6 results found for searched term "SIRT6-IN-3" (0.178 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41605 | SIRT6-IN-3 | Sirtuin |
| SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM). | ||
| M9876 | UBCS039 | Sirtuin |
| UBCS 039 | ||
| UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. | ||
| M11030 | SRT 1720 | Sirtuin |
| SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. | ||
| M27669 | E1231 | Sirtuin |
| 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one | ||
| E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. | ||
| M41601 | SIRT5 inhibitor 6 | Sirtuin |
| SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. | ||
| M41606 | SIRT6-IN-2 | Sirtuin |
| SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). | ||
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