About 23 results found for searched term "SIRT-IN-3" (0.164 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13736 | SIRT-IN-3 | Sirtuin |
| SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively). | ||
| M41600 | Sirt1/2-IN-3 | Sirtuin |
| Sirt1/2-IN-3 is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. | ||
| M41605 | SIRT6-IN-3 | Sirtuin |
| SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM). | ||
| M2598 | Inauhzin | p53 |
| INZ | ||
| Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). | ||
| M3010 | Sirtinol | Sirtuin |
| Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. | ||
| M4306 | Ganoderic-acid-D | Sirtuin |
| Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells. | ||
| M4460 | Oroxylin-A | CDK |
| Baicalein 6-methyl ether; 6-Methoxybaicalein | ||
| Oroxylin A is an active flavonoid that inhibits the phosphorylation of MDM2 and SIRT1 through the inhibition of CDK9, thus inhibiting MDM2-mediated degradation of P53 and SIRT1-mediated deacetylation of P53, and ultimately stabilizing the P53 protein.Oroxylin A has strong anticancer activity. | ||
| M5265 | Thiomyristoyl | Sirtuin |
| Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. | ||
| M6241 | Tenovin 6 Hydrochloride | Sirtuin |
| Tenovin 2 | ||
| Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively. | ||
| M7500 | YK 3-237 | Sirtuin |
| YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein. | ||
| M8978 | 3-TYP | Sirtuin |
| 3-(1H-1,2,3-triazol-4-yl) pyridine; 3TYP | ||
| 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively. | ||
| M9876 | UBCS039 | Sirtuin |
| UBCS 039 | ||
| UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. | ||
| M10109 | SRT2183 | Sirtuin |
| SRT-2183 | ||
| SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM. | ||
| M11030 | SRT 1720 | Sirtuin |
| SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. | ||
| M11201 | Nicotinamide riboside | Sirtuin |
| BETA-nicotinamide ribose;Beta-Nicotinamide Riboside | ||
| Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease. | ||
| M14856 | Quercetin dihydrate | PI3K |
| Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. | ||
| M27669 | E1231 | Sirtuin |
| 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one | ||
| E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. | ||
| M28898 | SIRT7 inhibitor 97491 | Sirtuin |
| SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.. | ||
| M29225 | PROTAC Sirt2 Degrader-1 | Sirtuin |
| PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM). | ||
| M41598 | Sirt1/2-IN-4 | Sirtuin |
| Sirt1/2-IN-4 is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. | ||
| M41601 | SIRT5 inhibitor 6 | Sirtuin |
| SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. | ||
| M41602 | SPC-180002 | Sirtuin |
| SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. | ||
| M41606 | SIRT6-IN-2 | Sirtuin |
| SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). | ||
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