About 1 result found for searched term "SEC inhibitor KL-1" (0.174 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M20775 | SEC inhibitor KL-1 | Apoptosis |
| KL-1 | ||
| SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | ||
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