About 26 results found for searched term "S1P Receptor" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28557 | Icanbelimod | S1P Receptor |
| S1p receptor agonist 1 | ||
| Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P1 receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). | ||
| M1712 | FTY720 hydrochloride | S1P Receptor |
| Fingolimod hydrochloride | ||
| Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. | ||
| M2428 | BAF312 | S1P Receptor |
| Siponimod | ||
| BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. | ||
| M2476 | SEW2871 | S1P Receptor |
| SEW-2871 | ||
| SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. | ||
| M3012 | SKI II | S1P Receptor |
| SphK-I2 | ||
| SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. | ||
| M5244 | Ozanimod | S1P Receptor |
| RPC1063 | ||
| Ozanimod (RPC1063) is a selective, orally active sphingosine-1-phosphate (S1P) receptor modulator that binds to S1PR1 and S1PR5, and can be used in studies related to ulcerative colitis (UC). | ||
| M7319 | Sphingosine-1-phosphate | S1P Receptor |
| S1P | ||
| Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. | ||
| M7398 | TC-SP 14 | S1P Receptor |
| TC-SP 14 is a potent S1P1 receptor agonist. | ||
| M7438 | TY 52156 | S1P Receptor |
| TY 52156 is a s1P3 receptor antagonist. | ||
| M7560 | Cenerimod | S1P Receptor |
| ACT-334441 | ||
| Cenerimod (ACT-334441) is a potentially first-in-class (first-in-class), potent, highly selective, orally active sphingosine 1-phosphate 1 (S1P1) receptor agonist with an EC50 value of 2.7 nM for use in studies related to systemic lupus erythematosus (SLE). | ||
| M7570 | Amiselimod hydrochloride | S1P Receptor |
| MT-1303 hydrochloride | ||
| Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. | ||
| M8784 | NIBR-0213 | S1P Receptor |
| NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist. | ||
| M10226 | Etrasimod (APD334) | S1P Receptor |
| APD-334 | ||
| Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor, with IC50 of 1.88 nM in CHO cells. | ||
| M40974 | VTX-002 | S1P Receptor |
| VTX-002 is an orally active, selective S1P receptor 1 modulator for studies related to ulcerative colitis. | ||
| M14001 | FTY720 (S)-Phosphate | S1P Receptor |
| (S)-FTY720P; (S)-FTY720 phosphate | ||
| FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. | ||
| M21193 | SAR247799 | S1P Receptor |
| S1P1 agonist 3 | ||
| The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways. | ||
| M28004 | Siponimod hemifumarate | LPL Receptor |
| BAF-312 hemifumarate | ||
| Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research. | ||
| M28144 | RP101075 | S1P Receptor |
| RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile. | ||
| M28232 | CYM50179 | LPL Receptor |
| CYM50179 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM. | ||
| M28339 | Vibozilimod | S1P Receptor |
| SCD-044 | ||
| Vibozilimod (SCD-044, example 33) is a S1P1 receptor agonist. | ||
| M28696 | Ozanimod hydrochloride | S1P Receptor |
| RPC-1063 hydrochloride | ||
| Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) . | ||
| M29857 | CAY10444 | LPL Receptor |
| BML-241 | ||
| CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors. | ||
| M30823 | Ceralifimod | LPL Receptor |
| ONO-4641 | ||
| Ceralifimod (ONO-4641) is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC50s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively. | ||
| M31389 | TRV045 | S1P Receptor |
| TRV045 is an S1P receptor modulator that can be used in studies related to central nervous system disorders. | ||
| M56239 | CYM5442 hydrochloride | LPL Receptor |
| CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. | ||
| M56238 | CYM50358 hydrochloride | LPL Receptor |
| CYM50358 hydrochloride is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. | ||
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