About 5 results found for searched term "RUNX-IN-1" (0.369 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30817 | RUNX1/ETO tetramerization-IN-1 | Others |
| RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC50=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model. | ||
| M41292 | RUNX-IN-1 | Apoptosis |
| RUNX-IN-1 covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. | ||
| M9498 | CADD522 | ROS |
| CADD522 is a novel small molecule inhibitor of RUNX2, downregulates RUNX2-mediated transcription of downstream target genes by inhibiting RUNX2-DNA binding, with an IC50 of 10 nM. | ||
| M27737 | NSC 140873 | Others |
| NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335). | ||
| M54847 | Ro5-3335 | Others |
| Ro 5-3335 | ||
| Ro5-3335 acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation. | ||
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