About 30 results found for searched term "Potassium Channel" (0.067 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2020 | GW9508 | GPR/FFAR |
| GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. | ||
| M2181 | ML133 hydrochloride | Potassium Channel |
| ML133 HCl | ||
| ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. | ||
| M2347 | (+)-Bicuculline | GABA Receptor |
| d-Bicuculline | ||
| (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. | ||
| M2946 | Pinacidil monohydrate | Potassium Channel |
| Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. | ||
| M3077 | Tolbutamide | Potassium Channel |
| HLS 831 | ||
| Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM, it is also an inhibitor of potassium channel, used for type II diabetes. | ||
| M3343 | Nicorandil | Potassium Channel |
| SG-75 | ||
| Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). | ||
| M3411 | Sotalol | Adrenergic Receptor |
| Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. | ||
| M3418 | Bupivacaine hydrochloride | Animal experimental anesthetics |
| Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain. | ||
| M3456 | Chlorpromazine hydrochloride | Potassium Channel |
| Sonazine | ||
| Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3957 | Mitiglinide calcium | Potassium Channel |
| KAD-1229,S21403 | ||
| Mitiglinide (KAD 1229, S 21403), a derivative of benzysuccinic acid, is a potassium channel antagonist developed with Kissei for the study of type 2 diabetes. | ||
| M4160 | Soyasaponin-Be | Potassium Channel |
| Dehydrosoyasaponin I (Soyasaponin Be; Dhs-i, a triterpenoid glycoside, is a potent and reversible calcium-activated potassium (MAxi-K) channel activator. | ||
| M4514 | Tetrandrine | Calcium Channel |
| NSC-77037; S,S-(+)-Tetrandrine; d-Tetrandrine | ||
| Tetrandrine (NSC-77037; D-tetrandrine) is a diphenylisoquinoline alkaloid that inhibits voltage-gated calcium channels (ICa) and Ca2+ -activated potassium channels. | ||
| M4633 | Atractyloside | Chloride Channel |
| Atractyloside potassium salt is a toxic diterpenoid glycoside, which can be isolated from the fruit of Atractyloside. Atractyloside potassium salt is a highly effective and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibited the chloride channel in rat heart mitochondrial membrane. | ||
| M5130 | Cisapride | 5-HT Receptor |
| R 51619; (±)-Cisaprid | ||
| Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. IC50 Value is 0.14 μM (EC50 for 5-HT4 receptor). | ||
| M5302 | ICA069673 | Potassium Channel |
| ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM. | ||
| M6580 | Cesium chloride | Potassium Channel |
| Cesium chloride is a potassium channel blocker; neuroprotective. | ||
| M6735 | Flupirtine maleate | Potassium Channel |
| Flupirtine maleate is a selective potassium channel opener, NMDA receptor antagonist and GABAA receptor modulator. | ||
| M7177 | Quinine hydrochloride | Potassium Channel |
| Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M7783 | Efaroxan hydrochloride | Others |
| (+)-Isomer is a selective α-adrenoceptor antagonist; (−)-isomer is an imidazoline ligand that induces insulin secretion, mediated by the blockade of ATP-sensitive potassium channels in pancreatic β cells; I1 imidazoline binding site antagonist. | ||
| M7842 | Halofantrine hydrochloride | Others |
| Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel. | ||
| M7936 | Mephetyl tetrazole | Potassium Channel |
| Mephetyl tetrazole is a potent, selective Kv1.5 potassium channel blocker with an IC50 value of 330 nM that selectively prolongs atrial effective response period (ERP) but has no effect on ventricular ERP. | ||
| M8016 | PD-118057 | Others |
| PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. | ||
| M8123 | Quinidine sulfate salt dihydrate | Others |
| Class IA antiarrhythmic; potassium channel blocker. | ||
| M8124 | Quinine hemisulfate salt monohydrate | Potassium Channel |
| Quinine hemisulfate salt monohydrate is a potassium channel inhibitor that inhibits voltage pulse-induced currents in the MT mSlo3 (KCa5.1) channel +100 mV with an IC50 of 169 μM.In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M8182 | SG-209 | Others |
| Potassium channel activator; analog of nicorandil; nitrate-free coronary vasodilator. | ||
| M8223 | VU591 | Potassium Channel |
| VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. | ||
| M8303 | Azimilide dihydrochloride | AChR/AChE |
| NE-10064 Dihydrochloride | ||
| Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. | ||
| M8494 | BMS 204352 | Others |
| BMS 204352 is a potassium channel modulator. | ||
| M8698 | Kurarinone | Potassium Channel |
| Kurarinone, a flavanone from Sophora flavescens roots, is a potent activator of the large-conductance calcium-activated potassium channel (BKCa channel). | ||
| M9394 | BMS-191011 | Potassium Channel |
| BMS-A | ||
| BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). | ||
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