About 30 results found for searched term "PROTAC Linker" (0.105 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M45166 | LWY713 | PROTAC |
| LWY713 is a PROTAC molecule targeting FLT3 with acetyl group as linker, which can selectively induce FLT3 degradation in CRBN and proteasome-dependent manner, with a DC50 of 0.64 nM and a Dmax of 94.8%, and possesses antitumor activity. | ||
| M9237 | dBET1 | Epigenetic Reader Domain |
| dBET1 is a potent BRD4 protein degrader with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 linked to NSC 527179 with a linker. | ||
| M9791 | 5-Ethynyl-2'-deoxyuridine | PROTAC Linker |
| Edu | ||
| 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M9838 | VH032-PEG6-C4-Cl | PROTAC |
| (S,R,S)-AHPC-PEG6-C4-Cl; E3 ligase Ligand-Linker Conjugates 9 | ||
| (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. | ||
| M10067 | Ac4GalNAz | PROTAC |
| N-azidoacetylgalactosamine-tetraacylated | ||
| Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M10416 | Ac4ManNAz | PROTAC Linker |
| N-azidoacetylmannosamine-tetraacylated | ||
| Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M14868 | L-Azidohomoalanine hydrochloride | PROTAC Linker |
| L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M14871 | Gefitinib-based PROTAC 3 | PROTAC |
| Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. | ||
| M21159 | SD-36 | PROTAC |
| SD-36 is a potent STAT3 PROTAC degradation agent (Kd=~50 nM) with a high selectivity compared to other STAT members. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase. | ||
| M21318 | Biotin-PEG4-amino-t-Bu-DADPS-C6-azide | PROTAC |
| Biotin-Dadps-azide | ||
| Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PROTAC linker, which belongs to the PEG class. It can be used for the synthesis of PROTAC molecules.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M21359 | DSPE-PEG-Biotin (MW 2000) | PROTAC Linker |
| DSPE-PEG-Biotin (MW 2000) is a PROTAC linker, which belongs to the PEG class. It can be used to synthesize PROTAC molecules. | ||
| M21518 | MRTX849 ethoxypropanoic acid | PROTAC Linker |
| MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2. | ||
| M25473 | HaloPROTAC3 | Ligand for E3 Ligase |
| VH285-PEG4-C4-Cl | ||
| HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker, and it is also a highly potent and efficacious degrader of GFP-HaloTag7 fusion proteins with a DC50 of 19 nM. | ||
| M27879 | 3-Mercaptopropionic acid NHS ester | PROTAC Linker |
| 3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M28222 | PROTAC AR Degrader-4 | PROTAC |
| PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). | ||
| M28253 | Ac4GlcNAlk | PROTAC Linker |
| Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M28867 | VH032-PEG5-C6-Cl | PROTAC |
| HaloPROTAC 2 | ||
| VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. | ||
| M28868 | dFKBP-1 | PROTAC |
| dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based Cereblon ligand and a linker. | ||
| M29225 | PROTAC Sirt2 Degrader-1 | Sirtuin |
| PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM). | ||
| M29378 | MS177 | PROTAC |
| MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest. | ||
| M29496 | PROTAC ERRα Degrader-1 | PROTAC |
| PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader. | ||
| M29528 | PROTAC CRBN Degrader-1 | PROTAC |
| PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. | ||
| M29585 | KB02-SLF | PROTAC |
| KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. | ||
| M29586 | KB02-JQ1 | PROTAC |
| KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1. | ||
| M30988 | Alkynyl Palmitic Acid | PROTAC Linker |
| Alk-C16 | ||
| Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M31078 | PROTAC AR Degrader-4 TFA | PROTAC |
| PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). | ||
| M31274 | NH2-C2-amido-C2-Boc | PROTAC Linker |
| NH2-C2-amido-C2-Boc is a PROTAC linker, which refers to the alkyl/ether composition. NH2-C5-NH-Boc can be used in the synthesis of a series of PROTACs, such as the PROTAC CDK2/9 Degrader-1. | ||
| M38621 | H-Hyp-OMe hydrochloride | ADC Linker |
| H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M38623 | Eicosanedioic acid | ADC Linker |
| Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis | ||
| M38624 | Boc-Hyp-OH | ADC Linker |
| Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
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