About 31 results found for searched term "PORT-6" (0.083 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40649 | PORT-6 | Adenosine Receptor |
| TT-10 | ||
| PORT-6 is an adenosine receptor A2aR inhibitor that can be used in a variety of tumor-related studies. | ||
| M2294 | Brefeldin A | ATPase |
| BFA; Cyanein; Decumbin | ||
| Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity. | ||
| M2960 | Probenecid | TRP Channel |
| Benemid | ||
| Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. | ||
| M5043 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response. | ||
| M5189 | AZD3965 | Monocarboxylate Transporter (MCT) |
| AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM. | ||
| M6255 | JPH203 | Autophagy |
| KYT-0353 | ||
| JPH203, a selective L-type amino acid transporter 1 (LAT1) inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. | ||
| M6664 | Desipramine hydrochloride | Dopamine Receptor |
| Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively. | ||
| M9202 | α-cyano-4-hydroxy-cinnamic acid | Monocarboxylate Transporter (MCT) |
| ACCA; α-CHCA | ||
| α-Cyano-4-hydroxycinnamic acid (α-CHCA) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. | ||
| M6849 | JNJ 63533054 | GPR/FFAR |
| JNJ-63533054 is a potent, selective, orally active GPR139 agonist.JNJ-63533054 is more selective for GPR139 than other GPCR, ion channel and transporter proteins.JNJ-63533054 can cross the blood-brain barrier (BBB). | ||
| M8623 | RSV604 (A-60444) | RSV |
| A-60444; RSV-604 | ||
| RSV604 (A-60444) is a cell-permeable, non-cytotoxic (CC50 >50 μM) benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N), with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM). | ||
| M8835 | UA62784 | Others |
| Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. | ||
| M8836 | U18666A | Anti-infection |
| U 18666A | ||
| U18666A is an intra-cellular cholesterol transport inhibitor. U18666A inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus. | ||
| M10023 | DL-TBOA | EAAT |
| DL-Threo-Beta-Benzyloxyaspartic acid | ||
| DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. | ||
| M10112 | Cinromide | Others |
| trans-3-Bromo-N-ethylcinnamamide | ||
| Cinromide is an inhibitor of epithelial neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 0.5 μM. | ||
| M10535 | Probenecid sodium | TRP Channel |
| Probenecid sodium is a sodium salt of Probenecid that is soluble in water. Probenecid (Benemid) is an organic anionic transport competitive inhibitor, as well as an agonist of transient receptor potential vanillin receptor subfamily 2(TRPV2) and an inhibitor of human bitter taste receptor TAS2R16. | ||
| M10744 | V-9302 | Others |
| V9302 | ||
| V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells. | ||
| M10815 | Elobixibat | Others |
| A 3309 | ||
| Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor, IC50 Values were 0.53±0.17 nM (human IBAT), 0.13±0.03 nM (mouse IBAT), 5.8± 1.6 nM (canine IBAT). | ||
| M11481 | Abatacept | Immunology/Inflammation |
| Orencia；CTLA4lg；BMS-188667 | ||
| Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. | ||
| M14244 | Furosemide sodium | Others |
| Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. | ||
| M14688 | DMT1 blocker 1 | Others |
| DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM, is expected to block iron uptake by enterocytes in vivo. | ||
| M14889 | GNF4877 | DYRK |
| GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||
| M18886 | Oleandrigenin | Others |
| Oleandrisenin | ||
| Oleandrigenin is a metabolite and an Na(+)/K(+)-transporting ATPase inhibitor. Oleandrigenin is a steroid ester that is the 16-acetyl derivative of gitoxigenin. | ||
| M19236 | Arecaidine | GABA Receptor |
| Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. | ||
| M20706 | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | ||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | ||
| M21047 | Diethyl phosphate | IL Receptor/Related |
| DEP, DPF, Diethyl phosphoric acid, diethyl hydrogen phosphate | ||
| Diethyl phosphate (DEP, DPF, Diethyl phosphoric acid, diethyl hydrogen phosphate), a non-specific metabolite of organophosphorus pesticides in the gut environment, significantly enriches opportunistic pathogens leading to a decrease in interleukin-6 (IL-6). | ||
| M21202 | Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; NGAL | ||
| Human neutrophil gelatinase-associated lipid transport protein (Lipocalin-2/NGAL/LCN2) is produced by the E. coli expression system and the target gene encoding Gln21-Gly198 has a 6His tag at the C-terminus.Protein number: P80188 | ||
| M21416 | Elobixibat hydrate | Others |
| A 3309 hydrate; AZD 7806 hydrate | ||
| Elobixibat hydrate is a potent bile acid transporter (IBAT) inhibitor with IC50 values of 0.53±0.17 nM (human IBAT), 0.13±0.03 nM (mouse IBAT), and 5.8±1.6 nM (canine IBAT). Elobixibat hydrate can be used in the study of chronic functional constipation (CIC) in the elderly. | ||
| M21589 | OM-153 | PARP |
| OM-153 is a potent, orally active tankyrase inhibitor with IC50 of 13 nM for tankyrase 1 and 2 nM for tankyrase 2 (TNKS1/2). OM-153 inhibited luciferase based Wnt/β-catenin signal transduction reporter activity with IC50 of 0.63 nM. OM-153 inhibits Wnt/β-catenin signal transduction and proliferation in COLO 320DM. | ||
| M22527 | Cinchonidine | Alkaloids |
| α-Quinidine | ||
| Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. | ||
| M24949 | Clervonafusp alfa | Others |
| VAL-1221 | ||
| Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research. | ||
| M24962 | Semorinemab | Others |
| RG 6100; RO7105705; MTAU-9937A | ||
| Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease. | ||
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