About 2 results found for searched term "PF-5274857" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2447 | PF-5274857 | Hedgehog |
| PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. | ||
| M28682 | PF-5274857 hydrochloride | Smo |
| PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. | ||
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