About 33 results found for searched term "PAT-IN-1" (0.065 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9073 | Apatinib | VEGFR/PDGFR |
| Apatinib free base; YN-968D1 | ||
| Apatinib is a selective VEGFR2 inhibitor with IC50 of 1 nM. | ||
| M41930 | PAT-IN-1 | Ras |
| PAT-IN-1 is a protein acyl transferases (PAT) inhibitor. | ||
| M42971 | GPAT-IN-1 | Others |
| GPAT-IN-1 is a glycerol-3-phosphate acyltransferase (GPAT) inhibitor with an IC50 value of 8.9 μM. | ||
| M10352 | Recombinant Human HGF (CHO-expressed) | Cytokines and Growth Factors |
| rhHGF; Hepatocyte Growth Factor (HGF), Human | ||
| Recombinant human Hepatocyte Growth Factor (rhHGF) , also known as hepatopoietin-A and scatter factor, is a pleiotropic mitogen belonging to the peptidase S1 family (plasminogen subfamily). It is produced by mesenchymal cells and acts on epithelial cells, endothelial cells and haemopoietic progenitor cells. | ||
| M1713 | GDC-0449 (Vismodegib) | Smo |
| Vismodegib, HhAntag691 | ||
| GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. | ||
| M1802 | Lapatinib ditosylate monohydrate | EGFR/HER2 |
| GW572016 ditosylate monohydrate; GW2016 | ||
| Lapatinib (GW572016) ditosylate monohydrate is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM). | ||
| M1844 | ITMN-191 | Proteasome |
| Danoprevir, RG7227 | ||
| ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM. | ||
| M2203 | Elbasvir | HCV Protease |
| MK-8742 | ||
| Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) replication complex inhibitor, with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively. | ||
| M2338 | LDE225 | Hedgehog |
| Sonidegib; NVP-LDE225; Erismodegib | ||
| LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||
| M2448 | GANT61 | Gli |
| NSC 136476 | ||
| GANT61 is a Gli1 and Gli2 inhibitor targeting the Hedgehog/GLi pathway that inhibits GLI1- and GLI2-induced transcription with an IC50 of 5 μM. In addition, GANT61 selectively acts on the transcription of other pathways such as TNF and glucocorticoid receptor genes. | ||
| M2476 | SEW2871 | S1P Receptor |
| SEW-2871 | ||
| SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. | ||
| M2553 | GS-5885 | HCV Protease |
| Ledipasvir | ||
| GS-5885 is an inhibitor of the hepatitis C virus (HCV) NS5A protein and exhibits potent suppression of genotype 1 HCV replicons. | ||
| M2782 | IWR-1-endo | Wnt/beta-catenin |
| endo-IWR 1; IWR-1 | ||
| IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M2990 | Rupatadine Fumarate | Histamine Receptor |
| Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively. | ||
| M3517 | Lapatinib | EGFR/HER2 |
| GW-572016; GW2016 | ||
| Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. | ||
| M3680 | GS-9451 | HCV Protease |
| GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). | ||
| M3713 | YS-49 | PI3K |
| YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. | ||
| M3886 | WAY-262611 | Wnt/beta-catenin |
| WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM. | ||
| M4062 | Punicalagin | Anti-infection |
| Punicalagin is a species from Punica Granatum L. Or polyphenols isolated from the leaves of Terminalia catappa L. Punicalagin is a reversible, noncompetitive 3CLpro inhibitor that inhibits SARS-COV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anticancer effects. Punicalagin has the potential to be used in COVID-19 research. | ||
| M4117 | Hederacolchiside-A1 | PI3K |
| Hederacolchiside A1, isolated from Pulsatilla pulsatilla, induces apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro. | ||
| M4228 | Neferine | NF-κB |
| (-)-Neferine | ||
| Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M4247 | Schizandrol-B | PCSK9 |
| Gomisin-B; Schizantherin-B; Wuweizi ester-B; Schisantherin-B | ||
| Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a lignan from Schisandra chinensis that promotes liver enlargement in mice through activation of the PXR and YAP pathways and inhibits PCSK9 protein expression with an IC50 value of 1.10 μM. | ||
| M4361 | Polyphyllin-I | JNK |
| Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. | ||
| M4433 | Alantolactone | STAT |
| (+)-Alantolactone; Alant camphor; Elecampane camphor; Eupatal; Inula camphor | ||
| Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone (helenin, helenine, Eupatal) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. | ||
| M4496 | Linderalactone | Apoptosis |
| Linderalactone is an important sesquiterpene lactone isolated from Radix Linderae. Linderalactone inhibits cancer cell growth by regulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. Linderalactone also inhibited the proliferation of lung cancer A-549 cells with an IC50 value of 15 µM. | ||
| M4507 | Scopolin | Sirtuin |
| Scopolin is a coumarin isolated from the roots of Arabidopsis. Scopolin mitigated hepatic steatosis by activating sirT1-mediated signaling cascades. | ||
| M4618 | Eupalinolide A | HSP |
| Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. | ||
| M4686 | Eriodictyol | Immunology/Inflammation |
| Huazhongilexone | ||
| Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM. | ||
| M4857 | Epothilone B | Microtubule |
| Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. | ||
| M6291 | 5-Iodotubercidin | PKA |
| NSC 113939, 5-ITu | ||
| 5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors. | ||
| M6661 | Deguelin | Akt |
| (-)-Deguelin; (-)-cis-Deguelin | ||
| Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. | ||
| M9487 | Tirzepatide hydrochloride | GLP Receptor |
| LY3298176 hydrochloride | ||
| Tirzepatide Hydrochloride is a glucose-dependent insulin-stimulating peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. | ||
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