About 15 results found for searched term "P-gb-IN-1" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42234 | P-gb-IN-1 | P-glycoprotein |
| P-gb-IN-1 inhibitor. | ||
| M9525 | Pamiparib | PARP |
| BGB-290 | ||
| Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively. | ||
| M9897 | GB1107 | Galectin |
| GB-1107 | ||
| GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules. | ||
| M20835 | Seralutinib (GB002) | VEGFR/PDGFR |
| PK10571 | ||
| Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively. | ||
| M22496 | Recombinant Mouse HMGB1 Protein (HEK293, hFc Tag) | Recombinant Proteins |
| High-mobility group box 1; HMG-1 | ||
| The recombinant mouse HMGB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a calculated molecular mass of 53.3 kDa. High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. | ||
| M22497 | Recombinant Human HMGB1 Protein (E. coli, C-His) | Recombinant Proteins |
| High Mobility Group Box-1; rHuHMGB1 | ||
| Human High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (a.a.) single chain polypeptide. | ||
| M24907 | Pegbelfermin | FGFR |
| BMS-986036 | ||
| Pegbelfermin (BMS-986036) is a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21). Pegbelfermin can be used for the research of nonalcoholic steatohepatitis (NASH). | ||
| M27810 | NecroX-7 | HMGB1 |
| NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research. | ||
| M28045 | GB83 | PAR |
| GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons. | ||
| M29180 | PDZ1i | FAK |
| 113B7 | ||
| PDZ1i is a potent, BBB-penetrated and specific MDA-9/Syntenin inhibitor. PDZ1i inhibits crucial GBM (glioblastoma multiforme) signaling involving FAK and EGFRvIII. PDZ1i reduces MMP secretion. PDZ1i can improve survival of brain tumor-bearing mice and reduce tumor invasion. | ||
| M29535 | cRIPGBM | RIPK |
| cRIPGBM, a proapoptotic derivative of RIPGBM, a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells. | ||
| M29536 | cRIPGBM chloride | RIPK |
| cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models. | ||
| M30608 | RGB-286147 | CDK |
| RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity. | ||
| M40344 | Tanshindiol B | Others |
| Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis). | ||
| M41911 | Prostaglandin B1 | Prostaglandin Receptor |
| Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1. | ||
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