About 2 results found for searched term "Onalespib" (0.081 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1949 | Onalespib | HSP |
| AT-13387; AT13387 | ||
| Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. | ||
| M27649 | Onalespib lactate | HSP |
| Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an Kd value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC). | ||
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