About 13 results found for searched term "OR-486" (0.176 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5601 | Duloxetine HCl | 5-HT Receptor |
| (S)-Duloxetine hydrochloride; LY-248686 hydrochloride | ||
| Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | ||
| M7085 | OR-486 | Others |
| OR-486 is a catechol O-methyltransferase inhibitor. | ||
| M3344 | Nefiracetam | GABA Receptor |
| DZL 221; DM9384 | ||
| Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions. | ||
| M4974 | GW4869 2HCl | Phospholipase |
| GW69A; GW554869A | ||
| GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. | ||
| M9475 | Sardomozide dihydrochloride | Others |
| Sardomozide 2HCl; CGP 48664A | ||
| Sardomozide dihydrochloride (also known as SAM486A or CGP48664) is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). | ||
| M10943 | Atabecestat | BACE |
| JNJ-54861911 | ||
| Atabecestat (JNJ-54861911) is a potent brain-osmotic and has oral activity β-position amyloid precursor protein lyase 1 (BACE1 inhibitors that strongly reduce the expression of Aβ protein in cerebrospinal fluid. Atabecestat (JNJ-54861911) is tolerant and has sustained pharmacokinetic (PK) and pharmacodynamic (PD) profiles. Atabecestat (JNJ-54861911) has the potential to be used in the study of Alzheimer's disease. | ||
| M13815 | GSK-3484862 | DNA Methyltransferase |
| GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates global demethylation in murine embryonic stem cells. | ||
| M28300 | Fobrepodacin disodium | Antibiotic |
| SPR720 disodium; pVXc-486 disodium | ||
| Fobrepodacin (SPR720) disodium is an orally active and potent phosphate proagent of SPR719 (VXc-486). Fobrepodacin disodium has potent bactericidal activities in vivo. | ||
| M28301 | Fobrepodacin | Antibiotic |
| SPR720; pVXc-486 | ||
| Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo. | ||
| M28634 | PF-06648671 | Gamma-secretase/Beta-secretase |
| PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease. | ||
| M29121 | JNJ-56022486 | GluR |
| JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood brain barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy. | ||
| M29741 | ZW4864 free base | Wnt/beta-catenin |
| ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. | ||
| M29742 | ZW4864 | Wnt/beta-catenin |
| ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. | ||
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