Necroptosis-IN-3 - Search Results

About 5 results found for searched term "Necroptosis-IN-3" (0.126 seconds)

Cat.No.	Name	Target
M31123	Necroptosis-IN-3	Apoptosis
	Necroptosis-IN-3, an inhibitor of necroptosis, inhibits TNF-α-induced necroptosis and also inhibits 11β-HSD1.
M58110	Recombinant Human RIPK3 Protein (E. coli, N-His)	Cytokines and Growth Factors
	RIP-like protein kinase 3; RIP3
	RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury.
M9062	Necrosulfonamide	Necroptosis
	NSA
	Necrosulfonamide is a necroptosis inhibitor which selectively targeting the mixed lineage kinase domain-like protein (MLKL) with IC50 value of 124 nM in human HT-29. Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors.
M13394	GSK2593074A	RIPK
	GSK'074
	GSK2593074A is a necroptosis inhibitor that inhibits RIP1 and 3.
M14173	GW806742X hydrochloride	Necroptosis
	GW806742X hydrochloride is an ATP mimetic and potent inhibitor of MLKL and necroptosis, slowing down MLKL membrane translocation and binding to the MLKL pseudokinase domain with a Kd value of 9.3 μM. GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM).