About 31 results found for searched term "NT160" (0.242 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M24995 | Melrilimab | IL Receptor/Related |
| GSK 3772847; CNTO-7160 | ||
| Melrilimab (GSK 3772847) is an IgG2-kappa anti-IL1RL1/ST2/IL33R/DER4/FIT-1 monoclonal antibody. Melrilimab can be used for the research of asthma. | ||
| M41493 | NT160 | HDAC |
| NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. | ||
| M2870 | MSDC-0160 | Others |
| Mitoglitazone; CAY10415 | ||
| MSDC 0160 (Mitoglitazone) is an insulin sensitizer that regulates the mitochondrial target of thiazolidinedione (mTOT) and a regulator of mitochondrial pyruvate vector (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has potential for use in Alzheimer's disease. | ||
| M3108 | UNC2250 | TAM Receptor |
| UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3. | ||
| M4867 | Pexidartinib | c-Kit |
| PLX3397; Turalio | ||
| Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. | ||
| M5233 | Osilodrostat | Mineralocorticoid Receptor |
| LCI699 | ||
| Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. | ||
| M6178 | Tucidinostat (Chidamide) | HDAC |
| HBI-8000; CS-055 | ||
| Tucidinostat (Chidamide) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. | ||
| M6249 | BMS-813160 | CCR |
| BMS813160 | ||
| BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. | ||
| M10894 | Ubrogepant | CGRP Receptor |
| MK-1602 | ||
| Ubrogepant (MK-1602) is a novel oral calcitonin gene-associated peptide receptor (CGRP) antagonist with the potential to be used in acute migraine studies. | ||
| M13443 | Recombinant Mouse IL-36 alpha (E.coli) | Cytokines and Growth Factors |
| IL-36 alpha (E.coli) | ||
| The recombinant mouse interleukin-36 α was produced by escherichia coli expression system and the target gene encoding ARG8-HIS160 was expressed. | ||
| M20620 | ONO-7300243 | Others |
| ONO 7300243, ONO7300243 | ||
| ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. | ||
| M21114 | Lenacapavir | HIV Protease |
| GS-6207 | ||
| Lenacapavir(GS-6207) is a first-in-class, long-acting HIV capsid inhibitor. Lenacapavir has anti-HIV activity with an EC50 of 100 pM in MT-4 cells and a mean EC50 of 50 pM (20-160 pM) against 23 clinical isolates of HIV-1 from different subtypes in peripheral blood mononuclear cells. | ||
| M27849 | ITK antagonist | Itk |
| ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM. | ||
| M28052 | GKT136901 hydrochloride | NADPH Oxidase |
| GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity. | ||
| M28169 | Osilodrostat phosphate | Mineralocorticoid Receptor |
| LCI699 phosphate | ||
| Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. | ||
| M28236 | OTS447 | FLT3 |
| OTS447 is a potent FLT3 inhibitor with an IC50 of 21 nM (WO2012016082A1, compound 335). | ||
| M28271 | XD14 | Epigenetic Reader Domain |
| XD14 is a potent BET inhibitor with antitumor effect. It binds to BRD2, BRD3, and BRD4 with Kds of 170, 380, and 160 nM, respectively. | ||
| M28373 | (±)-BI-D | HIV Protease |
| (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1] Target: integrase inhibitor in vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells . | ||
| M28643 | KDM5-C49 | Histone demethylase |
| KDOAM-20 | ||
| KDM5-C49 (KDOAM-20) is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 can be used for the research of cancer. | ||
| M29187 | SM1-71 | MAPKAPK2/MAP3K/MAP4K |
| SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. | ||
| M29454 | ZK824190 | Serine/Threonine Protease |
| ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. | ||
| M29552 | JHU37160 | AChR/AChE |
| JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue. | ||
| M29739 | ZK824190 hydrochloride | Serine/Threonine Protease |
| ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. | ||
| M30971 | GKT136901 | NADPH Oxidase |
| GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity. | ||
| M31015 | KDM5-C49 hydrochloride | Histone demethylase |
| KDOAM-20 hydrochloride | ||
| KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer. | ||
| M40519 | AOH1996 | DNA/RNA Synthesis |
| AOH1996 is an orally active small molecule PCNA inhibitor, which can be obtained by adding a methoxy group to the interstitial position of the benzene ring at the end of AOH1160, and enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II, as well as selectively kills cancer cells, which can be used in cancer-related research. | ||
| M40754 | Lenacapavir sodium | HIV Protease |
| GS-6207 sodium | ||
| Lenacapavir sodium is a first-in-class, long-acting HIV capsid inhibitor. Lenacapavir sodium has anti-HIV activity with an EC50 of 100 pM in MT-4 cells and an average EC50 of 50 pM (20-160 pM) in peripheral blood mononuclear cells against 23 clinical isolates of HIV-1 from different subtypes. | ||
| M43594 | Estrogen receptor antagonist 8 | Estrogen Receptor |
| Estrogen receptor antagonist 8 is a potent estrogen receptor ER antagonist with an EC50 of 4.160 μM. | ||
| M53176 | GLP-1 moiety from Dulaglutide | Glucagon Receptor |
| GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist, extracted from patent US 20160369010 A1. | ||
| M56953 | GPR132 antagonist 1 | Others |
| GPR132 antagonist 1 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. | ||
| M56087 | CP94253 hydrochloride | 5-HT Receptor |
| CP94253 hydrochloride is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay).Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively. | ||
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