About 9 results found for searched term "ND-646" (0.144 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9735 | ND-646 | Others |
| ND646 | ||
| ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. | ||
| M2482 | C646 | Histone Acetyltransferase |
| C 646 | ||
| C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases. | ||
| M8933 | EPZ011989 | Histone Methyltransferase |
| EPZ011989 is a potent, orally-available EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646. | ||
| M11279 | GNE-6468 | Others |
| Gne-6468 is a potent and selective RORγ (RORc) reverse agonist with an EC50 value of 2 nM. Gne-6468 inhibited IL-17 in PBMC with EC50 value of 30 nM. | ||
| M13846 | EPZ011989 trifluoroacetate | Histone Methyltransferase |
| EPZ-011989 trifluoroacetate | ||
| EPZ011989 trifluoroacetate is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. | ||
| M20976 | SB 200646 | 5-HT Receptor |
| SB 200646A | ||
| SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo. | ||
| M21588 | GSK2646264 | Syk |
| GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin. | ||
| M22456 | Recombinant ASFV p72 complex | Cytokines and Growth Factors |
| Recombinant ASFV p72 complex is produced by Mammalian expression system and the target gene encoding Met1-Thr646&Met1-Leu530 is expressed with a 10His-3*Flag tag and a Flag-Strep tag at the N-terminus. Protein p72 is the major capsid protein of African swine fever virus (ASFV) and is an important target for test and vaccine development. | ||
| M28006 | PF-05186462 | Sodium Channel |
| PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain. | ||
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