About 32 results found for searched term "NC-R17" (0.349 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M42428 | NC-R17 | Glutathione Peroxidase |
| NC-R17 is a RSL3-based noncovalent GPX4 degrader, involving in Ferroptosis. | ||
| M8703 | 8-Aminoguanine | Others |
| 8-amino-guanine, a guanine derivative, is an orally effective potassium-preserving diuretic/sodium compound that increases sodium excretion 17. | ||
| M8773 | Liarozole dihydrochloride | Others |
| Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) that targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyas |
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| M11492 | Recombinant Human Endostatin (P. pastoris) | Recombinant Proteins |
| Endostatin | ||
| Recombinant human Endostatin protein (P. pastoris) is determined by the formation of endothelial cells. Endostatin concentration of 10 μg/ mL showed obvious anti-angiogenesis effect. Protein structure: Endostatin (ALA1571-Lys1754), Accession # P39060. | ||
| M15033 | Recombinant Mouse IL-17A (CHO) | Recombinant Proteins |
| IL17A, CTLA-8 | ||
| Interleukin-17a (also known as CTLA-8) is a pleiotropic cytokine expressed by T cells and has a high degree of homology to the protein encoded by the ORF13 gene of herpetic virus squirrel monkey. Protein structure: IL-17A (ALA26-ALA158), Accession # Q62386. | ||
| M15017 | Recombinant Human TGFBR2 (Mammalian,C-Fc) | Recombinant Proteins |
| TGF-beta type II receptor | ||
| Recombinant human TGFBR2 protein (C-FC) is generated by Mammalian expression system, and the target gene encoding Thr23-ASP159 is expressed at the C-terminal with Fc label. Accession # : P37173. | ||
| M21373 | TAS-117 | Akt |
| TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (IC50 of 4.8, 1.6 and 44 nM for Akt1, 2 and 3, respectively).TAS-117 stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition.TAS-117 induces apoptosis and autophagy. autophagy). | ||
| M21511 | RGLS4326 | Others |
| RG4326 | ||
| RGLS4326 (RG4326) is a first-in-class microRNA-17 (miR-17) oligonucleotide inhibitor. RGLS4326 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 acts on HeLa cells to inhibit the function of miR-17 with EC50 value of 28.3 nM. | ||
| M21628 | 2'-Fucosyllactose | IL Receptor/Related |
| 2-FL | ||
| 2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines. | ||
| M21638 | Recombinant Human GPNMB (Mammalian, C-6His) | Recombinant Proteins |
| Glycoprotein Non-Metastatic Melanoma Protein B | ||
| Recombinant Human GPNMB (Glycoprotein Non-Metastatic Melanoma Protein B) is produced by Mammalian expression system and the target gene encoding Ala22-Pro486 is expressed with a 6His tag at the C-terminus. Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. | ||
| M21677 | Recombinant Human Follistatin 288 (Mammalian, C-6His) | Recombinant Proteins |
| FST; follistatin isoform FST317 | ||
| Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Recombinant Human Follistatin/FST is produced by Mammalian expression system and the target gene encoding Gly30-Asn317 is expressed with a 6His tag at the C-terminus. | ||
| M21705 | Recombinant Mouse IL-17F (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-17F | ||
| Recombinant Mouse Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. | ||
| M21706 | Recombinant Human IL-17F (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-17F human | ||
| Recombinant Human Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed with a 6His tag at the C-terminus. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. | ||
| M21723 | Recombinant Human IL-17F (Mammalian) | Recombinant Proteins |
| Interleukin-17F | ||
| Recombinant Human Interleukin-17F is produced by our Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed. IL-17F can stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. The ED50 of Human IL-17F is 24.21 ng/ml. | ||
| M22527 | Cinchonidine | Alkaloids |
| α-Quinidine | ||
| Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. | ||
| M25496 | DRI-C21045 | TNF Receptor |
| DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively. | ||
| M27929 | BMS-817399 | CCR |
| BMS-817399 is a potent, selective, and orally bioavailable CCR1 antagonist. BMS-817399 exhibits CCR1 binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC50), respectively. BMS-817399 can be used for the research of rheumatoid arthritis. | ||
| M28184 | Debio 0617B | STAT |
| Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors. | ||
| M28214 | UNC10217938A | Others |
| UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides. | ||
| M28302 | SR1555 | ROR |
| SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases. | ||
| M28314 | MRL-871 | ROR |
| MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. | ||
| M28775 | UNC-2170 | Others |
| UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB). | ||
| M28849 | MC1742 | HDAC |
| MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC. | ||
| M28961 | TH1217 | Anti-infection |
| ZINC1775962367 | ||
| TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19. | ||
| M29140 | A-9758 | ROR |
| A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation. | ||
| M29145 | PF-06445974 | PDE |
| PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC50 <1 nM. The IC50 values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study. | ||
| M29507 | ERD-308 | PROTAC |
| ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively). | ||
| M29598 | FM26 | ROR |
| FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. | ||
| M30616 | Aderbasib | MMP |
| INCB007839; INCB7839 | ||
| Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al. | ||
| M30723 | LT175 | PPAR |
| LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties. | ||
| M31361 | Recombinant Human MRAP Protein (HEK293, hFc Tag) | Recombinant Proteins |
| Melanocortin 2 Receptor Accessory Protein; FALP; B27 | ||
| MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. A DNA sequence encoding the human MRAP (Tyr59-Ser172) was expressed with the Fc region of human IgG1 at the N-terminus. | ||
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