About 17 results found for searched term "NADPH Oxidase" (0.134 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6452 | Apocynin | NADPH Oxidase |
| Acetovanillone | ||
| Apocynin is a nADPH-oxidase inhibitor. | ||
| M6970 | ML171 | NADPH Oxidase |
| 2-Acetylphenothiazine; 2-APT | ||
| ML171 is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay. | ||
| M8274 | VAS2870 | NADPH Oxidase |
| VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC. | ||
| M9608 | APX-115 | NADPH Oxidase |
| Ewha-18278; APX-115 free base | ||
| APX-115 is a potent, orally active inhibitor of pan NADPH oxidase (Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. | ||
| M9726 | GLX351322 | NADPH Oxidase |
| GLX351322 is an NADPH oxidase 4 inhibitor, which inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. | ||
| M10049 | GSK2795039 | NADPH Oxidase |
| GSK-2795039 | ||
| GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor, with a mean pIC50 of 6 in different cell-free assays. | ||
| M10495 | AMI-1 disodium salt | PRMTs |
| AMI1 | ||
| AMI-1 is a potent and selective, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50 values of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 is also a potent scavenger of NADPH-oxidase-derived superoxide. | ||
| M10995 | Daphnoretin | PKC |
| Dephnoretin | ||
| Daphnoretin (Dephnoretin) is extracted from Wikstroemia indica and has antiviral activity. Daphnoretin acts similarly to PMA in that it can directly activate protein kinase C, thereby activating NADPH oxidase. | ||
| M20838 | Fluorofenidone | Others |
| AKF-PD | ||
| Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway. | ||
| M21418 | CL097 | TLR |
| CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production. | ||
| M28052 | GKT136901 hydrochloride | NADPH Oxidase |
| GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity. | ||
| M30760 | VAS 3947 | NADPH Oxidase |
| VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. | ||
| M30971 | GKT136901 | NADPH Oxidase |
| GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity. | ||
| M31297 | WKYMVM acetate | FPR |
| WKYMVM acetate is a potent agonist of the N-formyl peptide receptors FPR1 and FPRL1/2, and also activates a number of leukocyte effector functions such as chemotaxis, activation of complement receptor-3 and NADPH oxidase. | ||
| M52559 | NoxA1ds | NADPH Oxidase |
| NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. | ||
| M53908 | WKYMVM | FPR |
| WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase. | ||
| M54382 | Ac9-25 | FPR |
| Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR. | ||
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