About 11 results found for searched term "MTH1" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42496 | MTHFD2-IN-1 | Dehydrogenase |
| MTHFD2-IN-1 is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor. | ||
| M2350 | (S)-crizotinib | MTH1 |
| (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM. | ||
| M4357 | 3-Isomangostin | DNA/RNA Synthesis |
| 3 - Isomangostin from Garciniamangostana. L. Extracted from shell, 3-isomangostin is an effective MutT homolog 1 (MTH1) inhibitor with IC50 value of 52 nM. 3-Isomangostin can be used to develop anticancer agents. | ||
| M8899 | TH588 | MTH1 |
| TH588 is a first-in-class, potent, selective MTH1 (NUDT1) inhibitor with an IC50 value of 5 nM. | ||
| M13654 | TH287 | DNA/RNA Synthesis |
| TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. | ||
| M14691 | DS18561882 | Others |
| DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). | ||
| M14724 | LY 345899 | Dehydrogenase |
| LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1. | ||
| M29249 | BAY-707 | DNA/RNA Synthesis |
| BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy. | ||
| M29453 | TH5427 hydrochloride | DNA/RNA Synthesis |
| TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. | ||
| M29534 | DS44960156 | Dehydrogenase |
| DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively. | ||
| M56224 | Amthamine | Histamine Receptor |
| Amthamine is a histamine receptor (H1R-H4R) agonist. | ||
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