About 5 results found for searched term "Leflunomide" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2229 | Leflunomide | DHODH |
| HWA486; RS-34821; SU101 | ||
| Leflunomide (HWA486) is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. | ||
| M3059 | Teriflunomide | DHODH |
| A 77-1726; A771726; HMR1726; CAS# 108605-62-5 | ||
| Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. | ||
| M28093 | DHODH-IN-11 | DHODH |
| DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. | ||
| M54617 | Laflunimus | DHODH |
| HR325 | ||
| Laflunimus is an analog of the active metabolite of Leflunomide, A771726, and an orally active inhibitor of dihydroorotic acid dehydrogenase (DHODH) and prostaglandin endoperoxide synthase (PGHS). In addition, Laflunimus inhibits immunoglobulin (Ig) secretion with IC50 values of 2.5 and 2 μM for Ig M and IgG secretion, respectively. | ||
| M54629 | DHODH-IN-12 | DHODH |
| DHODH-IN-12 is a Leflunomide derivative and a weak inhibitor of dihydroorotic acid dehydrogenase (DHODH), with a pKa of 5.07. | ||
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