About 32 results found for searched term "LL-25" (0.067 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8141 | Rottlerin | PKC |
| Mallotoxin; NSC 56346; NSC 94525 | ||
| Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. | ||
| M53516 | LL-25 | Antifungal |
| LL-25 is a fragment of LL-37 but devoid of the immunomodulatory properties of LL-37. | ||
| M1765 | Crizotinib (PF-02341066) | c-Met |
| Crizotinib | ||
| Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. | ||
| M1908 | VER-82576 | HSP |
| NVP-BEP800; VER82576 | ||
| VER-82576 (NVP-BEP800) is a potent, orally available and selective inhibitor of Hsp90β with an IC50 of 58 nM. VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively. | ||
| M2225 | Thalidomide | Ligand for E3 Ligase |
| Thalomid | ||
| Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM. | ||
| M2354 | 1-Azakenpaullone | GSK-3 |
| 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. | ||
| M2434 | BAY 1000394 | CDK |
| Roniciclib | ||
| BAY 1000394 is an orally bioavailable pan-CDK inhibitor for CDK1/2/3/4/7/9 with IC50 of 5-25 nM. It also potently inhibits Aurora A, Clk2, ARK5, FGFR1, Flt3, and JAK2/3. Phase 1/2. | ||
| M2690 | Ethoxzolamide | Carbonic Anhydrase |
| Redupresin; L-643786; PNU-4191 | ||
| Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively. | ||
| M3146 | CX-6258 | Pim |
| CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. | ||
| M3550 | Vinorelbine | Microtubule |
| KW-2307 base | ||
| Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. | ||
| M2759 | Darapladib | Phospholipase |
| SB-480848 | ||
| Darapladib (SB-480848) is a selective and orally active inhibitor of Lp-PLA2 with IC50 of 0.25 nM. | ||
| M3970 | Scutellarin | STAT |
| Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. | ||
| M9117 | W-54011 | Immunology/Inflammation |
| W-54011 HCl | ||
| W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist, which inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. | ||
| M4450 | Acteoside | PKC |
| Verbascoside; Kusaginin; TJC160 | ||
| Acteoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||
| M4939 | CX-6258 hydrochloride hydrate | Pim |
| CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. | ||
| M5026 | UNC-2025 | FLT3 |
| UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties. | ||
| M5236 | BI-847325 | MEK |
| BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. | ||
| M5277 | B02 | DNA/RNA Synthesis |
| B-02 | ||
| B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). | ||
| M5321 | CX-6258 HCl | Pim |
| CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. | ||
| M6314 | SHP099 | Phosphatase |
| SHP099 free base | ||
| SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. | ||
| M6457 | AR-C 118925XX | P2 Receptor |
| ARC118925XX | ||
| AR-C 118925XX is a selective, competitive P2Y2 receptor antagonist. AR-C 118925XX is inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). AR-C 118925XX inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM). | ||
| M6649 | CZC-25146 | LRRK2 |
| CZC25146 | ||
| CZC 25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. | ||
| M7790 | Emodin | Casein Kinase |
| Frangula emodin | ||
| Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. | ||
| M8090 | PF-04965842 | JAK |
| Abrocitinib | ||
| Abrocitinib is an orally active and selective JAK1 inhibitor with an IC50 value of 29 nM. Abrocitinib reversibly inhibits JAK1 kinase by blocking its ATP-binding site. Abrocitinib (PF-04965842) inhibited TYK2 activity (IC50, 1.253 μM) and phosphorylation of STAT1, STAT3, and STAT5 after stimulation. It can be used in the study of autoimmune diseases. | ||
| M8189 | STF-62247 | Autophagy |
| STF62247; STF 62247 | ||
| Stf-62247 is an autophagy inducer with selective cytotoxicity against VHL-deficient renal cell carcinoma, with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. Stf-62247 can trigger ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M9094 | EG00229 Trifluoroacetate salt | VEGFR/PDGFR |
| EG-00229 Trifluoroacetate | ||
| EG00229 Trifluoroacetate is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM (125I-VEGF binding to PAE/NRP1 cells). | ||
| M9096 | H2DCFDA | Fluorescent Dye |
| DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate | ||
| H2DCFDA is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm). H2DCFDA can be used for the Bacterial reactive oxygen species (ROS) production assay. | ||
| M9313 | 25-Hydroxycholesterol | Others |
| 25-Hydroxycholesterol is a cholesterol metabolite produced and secreted by macrophages in response to toll-like receptor (TLR) activation. 25-Hydroxycholesterol effectively and selectively inhibited IgA production in B cells with EC50 of about 65 nM. | ||
| M9509 | NS-3-008 hydrochloride | Immunology/Inflammation |
| NS-3-008 hcl | ||
| NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. | ||
| M10177 | Collagenase IV | Enzymes & Coenzymes |
| Type IV collagenase, ≥125 CDU/mg solid ( CDU = collagen digestion units ) is especially suitable for the digestion of islet tissue. | ||
| M10727 | Pulrodemstat benzenesulfonate | Histone demethylase |
| CC-90011 benzenesulfonate | ||
| CC-90011 (Pulrodemstat) benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity. | ||
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