About 19 results found for searched term "L-Dihydroorotic acid" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21337 | L-Dihydroorotic acid | Metabolite/Endogenous Metabolite |
| L-dihydroorotate | ||
| L-dihydroorotic acid (L-dihydroorotate) is an intermediate product of pyrimidine metabolism that can be reversibly hydrolyzed by dihydroorotase to yield acyclic L-ureidosuccinic acid. | ||
| M57367 | DL-Dihydroorotic acid | Others |
| DL-Dihydroorotic acid | ||
| M17443 | Lapachol | DHODH |
| Lapachol is a naturally occurring naphthoquinone and orally active, potent inhibitor of dihydroorotic acid dehydrogenase (DHODH).Lapachol has immunosuppressive activity against lymphocytes by inhibiting pyrimidine synthesis through direct blockade of DHODH activity. In addition, Lapachol is a vitamin K antagonist with antitumor and antileishmanial activity that inhibits DNA and RNA synthesis in tumor cells. | ||
| M18400 | Ginkgolic Acid C17:2 | DHODH |
| Ginkgolic Acid C17:2 targets human dihydroorotic acid dehydrogenase (DHODH). | ||
| M20621 | ML390 | DHODH |
| ML390 is a human dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 value of 0.56 μM.Additionally, ML390 is an inducer of myeloid differentiation in acute myeloid leukemia (AML) cells. | ||
| M22180 | DSM265 | DHODH |
| DSM265 is a long-acting inhibitor of Plasmodium falciparum dihydroorotic acid dehydrogenase (PfDHODH) with an IC50 value of 8.9 nM. In addition, DSM265 inhibits the growth of Pf3D7 with an EC50 value of 4.3 nM. | ||
| M31108 | Olorofim | Dehydrogenase |
| Olorofim is an orally active, novel dihydroorotic acid dehydrogenase inhibitor that also targets pyrimidine biosynthesis in mycobacteria and has antifungal activity. | ||
| M45262 | KIO-301 | HCN Channel |
| KIO-301 a photoswitchable HCN channel blocker, and dihydroorotic acid ester dehydrogenase (DHODH) inhibitor for studies related to ocular diseases. | ||
| M50203 | BAY-2927088 | Others |
| BAY-2927088 is a selective dihydroorotic acid dehydrogenase (DHODH) inhibitor and tyrosine kinase inhibitor (TKI) that acts by blocking the activity of proteins of EGFR and/or HER2.BAY-2927088 can be used in studies related to non-small cell lung cancer (NSCLC). | ||
| M54617 | Laflunimus | DHODH |
| HR325 | ||
| Laflunimus is an analog of the active metabolite of Leflunomide, A771726, and an orally active inhibitor of dihydroorotic acid dehydrogenase (DHODH) and prostaglandin endoperoxide synthase (PGHS). In addition, Laflunimus inhibits immunoglobulin (Ig) secretion with IC50 values of 2.5 and 2 μM for Ig M and IgG secretion, respectively. | ||
| M54629 | DHODH-IN-12 | DHODH |
| DHODH-IN-12 is a Leflunomide derivative and a weak inhibitor of dihydroorotic acid dehydrogenase (DHODH), with a pKa of 5.07. | ||
| M54626 | DHODH-IN-8 | DHODH |
| DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotic acid dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM and Ki of 0.016 μM and 5.6 μM, respectively.DHODH-IN-8 exhibits antimalarial activity. | ||
| M54625 | DHODH-IN-14 | DHODH |
| DHODH-IN-14 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for hepatic DHODH in rats.DHODH-IN-14 can be used in rheumatoid arthritis-related studies. | ||
| M54621 | DHODH-IN-23 | DHODH |
| DHODH-IN-23 is an orally active dihydroorotic acid dehydrogenase (DHODH) inhibitor for cancer-related studies. | ||
| M54616 | DHODH-IN-17 | DHODH |
| DHODH-IN-17 is a 2-anilinoylnicotinic acid and an inhibitor of human dihydroorotic acid dehydrogenase (DHODH) (IC50=0.40 μM).DHODH-IN-17 can be used in studies related to acute myeloid leukemia (AML). | ||
| M54630 | DHODH-IN-13 | DHODH |
| DHODH-IN-13 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for hepatic DHODH in rats.DHODH-IN-13 can be used in rheumatoid arthritis-related studies. | ||
| M54623 | DHODH-IN-15 | DHODH |
| DHODH-IN-15 is a Hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH.DHODH-IN-15 may be useful for rheumatoid arthritis related studies. | ||
| M54620 | hDHODH-IN-1 | DHODH |
| hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity. hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase inhibitor with anti-inflammatory activity. | ||
| M54615 | CHIKV-IN-2 | DHODH |
| CHIKV-IN-2 is a potent inhibitor of chikungunya virus (CHIKV) with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. In addition, CHIKV-IN-2 exhibits inhibitory activity against dihydroorotic acid dehydrogenase (DHODH). | ||
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