About 2 results found for searched term "KRAS inhibitor-22" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41935 | KRAS inhibitor-22 | Ras |
| KRAS inhibitor-22 is a potent inhibitor of K-Ras. | ||
| M58664 | AMG410 | Ras |
| AMG-410 | ||
| AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. | ||
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