About 1 result found for searched term "KME-2780" (0.11 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M59167 | KME-2780 | IRAK |
| KME2780 | ||
| KME-2780 is the orally active inhibitor for IRAK1 and IRAK4, with IC50 values of 19 nM and 0.5 nM, respectively. KME-2780 promotes differentiation of leukaemia stem/progenitor cells (LSPCs), upregulates CD38 expression, and induces heterogeneous morphological alterations. KME-2780 exhibits antitumour activity against AML cells in a mouse xenograft model. | ||
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