About 14 results found for searched term "Immuno modulator-1" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41373 | Immuno modulator-1 | TNF Receptor |
| Immuno modulator-1 inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. | ||
| M1976 | Pomalidomide | Ligand for E3 Ligase |
| Actimid, CC-4047 | ||
| Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM. | ||
| M2225 | Thalidomide | Ligand for E3 Ligase |
| Thalomid | ||
| Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM. | ||
| M2560 | Y-320 | Others |
| Y320 | ||
| Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. | ||
| M6189 | Ossirene | IL Receptor/Related |
| AS101 | ||
| Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta (IL-1β) converting enzyme. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene also inhibits Caspase-1. | ||
| M10198 | Zabedosertib | IRAK |
| BAY1834845 | ||
| Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. | ||
| M14326 | Avadomide | E1/E2/E3 Enzyme |
| CC 122 | ||
| Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines. | ||
| M17865 | Euphol | Triterpenoids |
| Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). | ||
| M19195 | Physalin F | Apoptosis |
| Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection. | ||
| M21612 | Recombinant Mouse IFN-beta Protein (HEK293) | Cytokines and Growth Factors |
| IFN-beta; IFNB Protein | ||
| Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL. | ||
| M24784 | Faralimomab | Others |
| 64G12 | ||
| Faralimomab (64G12) is an immunomodulator, and a murine anti-IFNA1 IgG1 mAb. | ||
| M28522 | Levamisole | AChR/AChE |
| (-)-Tetramisole | ||
| Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active. | ||
| M29469 | SM-360320 | TLR |
| CL-087 | ||
| SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. | ||
| M54520 | TC11 | Caspase |
| TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death. | ||
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