About 15 results found for searched term "IDR-1" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6816 | IDRA 21 | Others |
| IDRA 21 is a inhibits AMPA receptor desensitization. | ||
| M50517 | IDR 1002 | Others |
| IDR 1002 is an IPO-38 antibody marker protein. | ||
| M54163 | IDR-1 | Antibiotic |
| IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. | ||
| M5193 | KS176 | BCRP/ABCG2/MXR/ABCP |
| KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter with IC50 values of 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays, respectively. | ||
| M5826 | Nylidrin hydrochloride | Others |
| Buphenine hydrochloride | ||
| Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices. | ||
| M6965 | MK-571 sodium salt | Others |
| MK-571 sodium salt is a selective, orally active CysLT1 receptor antagonist. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). | ||
| M20836 | Indirubin-3′-oxime | GSK-3 |
| IDR3O, I3O | ||
| Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. | ||
| M22179 | Dofequidar | P-glycoprotein |
| MS-209 | ||
| Dofequidar is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. | ||
| M27726 | Clitocine | Apoptosis |
| Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity. | ||
| M27792 | Capreomycin | Antibiotic |
| Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation[1][2] | ||
| M28721 | Sofpironium bromide | AChR/AChE |
| BBI 4000 | ||
| Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes. | ||
| M29668 | YS-370 | P-glycoprotein |
| YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. | ||
| M29898 | Ceefourin 1 | Others |
| Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma. | ||
| M30871 | Tenofovir exalidex | HIV Protease |
| CMX-157 | ||
| Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV. | ||
| M41282 | 5-NIdR | Apoptosis |
| 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide. | ||
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