About 14 results found for searched term "His 11" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M50469 | His 11 | Others |
| His11 is consists of a contiguous series of amino acid residues. | ||
| M51255 | Histone H3 (116-136), C116-136 | Others |
| Histone H3 (116-136), C116-136 is a peptide spaning the C-terminus of histone H3, amino acids 116 to 136. | ||
| M2275 | JIB-04 | Histone demethylase |
| JIB-04 is a selective inhibitor of Jumonji histone demethylase with IC50 values of 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. | ||
| M2971 | Pyrilamine Maleate | Histamine Receptor |
| Mepyramine Maleate | ||
| Pyrilamine is a histamine H1 receptor inverse agonist, it binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. | ||
| M1458 | SIS17 | HDAC |
| SIS17 is a histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. | ||
| M4597 | Silicristin | Monocarboxylate Transporter (MCT) |
| Silychristin is a flavonoid rich in milk thistle fruits, which has antioxidant effects. Silychristin is an effective inhibitor of thyroid hormone transporter MCT8 and can strongly inhibit T3 uptake with IC50 of 110 nM. | ||
| M20515 | Emedastine | Histamine Receptor |
| Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). | ||
| M20864 | L-2-Hydroxyglutaric acid disodium | Histone demethylase |
| (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG | ||
| L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively. | ||
| M21411 | Recombinant Rat S100A8 (E.coli , C-6His) | Cytokines and Growth Factors |
| Protein S100-A8; Calgranulin-A | ||
| Recombinant rat S100 calcium-binding protein A8 is produced by the E. coli expression system and the target gene encoding Met1-Glu89 has a 6His tag at the C-terminus. Protein ID:P50115. | ||
| M21471 | Recombinant Human Transferrin (HEK293, C-6His) | Cytokines and Growth Factors |
| Serotransferrin; Transferrin; Beta-1 metal-binding globulin | ||
| Recombinant human transferrin is produced by mammalian expression system, and the target gene is encoded as Val20-Pro698, which is expressed by 6His marker at the C-terminal. Protein number: AAA61140.1. | ||
| M28474 | HDAC3-IN-T247 | HDAC |
| HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells. | ||
| M28973 | CM-675 | PDE |
| CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease. | ||
| M40605 | Snail/HDAC-IN-1 | HDAC |
| Snail/HDAC-IN-1 is a potent Snail/HDAC dual-targeting inhibitor with strong inhibitory activity against HDAC1 with an IC50 value of 0.405 μM, and against Snail with a Kd of 0.18 μM. In addition, Snail/HDAC-IN-1 also increases histone H4 acetylation and decreases Snail protein expression in HCT-116 cells, thereby inducing apoptosis. In addition, Snail/HDAC-IN-1 also increased histone H4 acetylation in HCT-116 cells and decreased Snail protein expression, thereby inducing apoptosis. | ||
| M54532 | IDH1 Inhibitor 2 | Isocitrate Dehydrogenase (IDH) |
| IDH1 Inhibitor 2 is a potent wild-type IDH1 inhibitor that acts through covalent modification of His315 and has an IC50 value of 110 nM. | ||
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