About 14 results found for searched term "Hedgehog IN-5" (0.149 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43556 | Hedgehog IN-5 | Hedgehog |
| Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. | ||
| M1713 | GDC-0449 (Vismodegib) | Smo |
| Vismodegib, HhAntag691 | ||
| GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. | ||
| M2338 | LDE225 | Hedgehog |
| Sonidegib; NVP-LDE225; Erismodegib | ||
| LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||
| M2447 | PF-5274857 | Hedgehog |
| PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. | ||
| M2448 | GANT61 | Gli |
| NSC 136476 | ||
| GANT61 is a Gli1 and Gli2 inhibitor targeting the Hedgehog/GLi pathway that inhibits GLI1- and GLI2-induced transcription with an IC50 of 5 μM. In addition, GANT61 selectively acts on the transcription of other pathways such as TNF and glucocorticoid receptor genes. | ||
| M4841 | LDE225 (Sonidegib) diphosphate | Smo |
| NVP-LDE225; Erismodegib; Sonidegib diphosphate | ||
| LDE225 Diphosphate (Sonidegib diphosphate) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||
| M6149 | Ciliobrevin A | Hedgehog |
| HPI-4; Hedgehog Pathway Inhibitor 4 | ||
| Ciliobrevin A (HPI-4) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. | ||
| M6843 | JK184 | Hedgehog |
| JK184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. JK184 inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro. | ||
| M15084 | Recombinant Mouse Sonic Hedgehog/Shh (E.coli) | Cytokines and Growth Factors |
| Sonic Hedgehog Protein; SHH; HHG-1; SHH | ||
| Recombinant mouse Sonic Hedgehog gene was prepared by escherichia coli expression system and the target gene encoding Cys25-Gly198 was expressed. Accession # : Q62226. | ||
| M27901 | TAK-441 | Hedgehog |
| TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC50value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors. | ||
| M39852 | Physalin H | Hedgehog |
| Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively. | ||
| M43555 | Hedgehog IN-2 | Hedgehog |
| Hedgehog IN-2 is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells. | ||
| M43557 | Hedgehog IN-3 | Hedgehog |
| Hedgehog IN-3 is a hedgehog pathway inhibitor (IC50 = 0.01 µM). | ||
| M45320 | TPB15 | Hedgehog |
| TPB15 is an orally potent Hh (Hedgehog) signaling inhibitor that significantly induces MDA-MB-468 cell cycle arrest and apoptosis. TPB15 also blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. In addition, TPB15 can inhibit the expression of downstream regulator Glioma-associated oncogene 1 (Gli1). TPB15 has good anti-tumor activity and low toxicity. | ||
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