About 9 results found for searched term "Hedgehog IN-2" (0.215 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43555 | Hedgehog IN-2 | Hedgehog |
| Hedgehog IN-2 is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells. | ||
| M1713 | GDC-0449 (Vismodegib) | Smo |
| Vismodegib, HhAntag691 | ||
| GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. | ||
| M2338 | LDE225 | Hedgehog |
| Sonidegib; NVP-LDE225; Erismodegib | ||
| LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||
| M2448 | GANT61 | Gli |
| NSC 136476 | ||
| GANT61 is a Gli1 and Gli2 inhibitor targeting the Hedgehog/GLi pathway that inhibits GLI1- and GLI2-induced transcription with an IC50 of 5 μM. In addition, GANT61 selectively acts on the transcription of other pathways such as TNF and glucocorticoid receptor genes. | ||
| M4841 | LDE225 (Sonidegib) diphosphate | Smo |
| NVP-LDE225; Erismodegib; Sonidegib diphosphate | ||
| LDE225 Diphosphate (Sonidegib diphosphate) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||
| M6843 | JK184 | Hedgehog |
| JK184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. JK184 inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro. | ||
| M15057 | Recombinant Human Sonic Hedgehog/Shh (E.coli) | Cytokines and Growth Factors |
| SHH; HHG-1 | ||
| Recombinant Human Sonic Hedgehog is produced by E.coli expression system and the target gene encoding Cys24-Gly197 is expressed. | ||
| M15083 | Recombinant Human Sonic Hedgehog/Shh (E.coli, C24II) | Cytokines and Growth Factors |
| SHH; HHG-1 | ||
| Recombinant human Sonic Hedgehog gene was produced by escherichia coli expression system and the target gene encoding CYS24-Gly197 (C24II) was expressed. | ||
| M15084 | Recombinant Mouse Sonic Hedgehog/Shh (E.coli) | Cytokines and Growth Factors |
| Sonic Hedgehog Protein; SHH; HHG-1; SHH | ||
| Recombinant mouse Sonic Hedgehog gene was prepared by escherichia coli expression system and the target gene encoding Cys25-Gly198 was expressed. Accession # : Q62226. | ||
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