HSP90-IN-20 - Search Results | AbMole BioScience

About 4 results found for searched term "HSP90-IN-20" (0.13 seconds)

Cat.No.	Name	Target
M41514	HSP90-IN-20	HSP
	HSP90-IN-20 is a potent HSP90 inhibitor with an IC50 of ≤10 μM.
M20676	Pimitespib	HSP
	TAS-116
	TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).
M28763	YZ129	HSP
	YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.
M28960	CPUY201112	HSP
	CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research.