About 10 results found for searched term "HMG-CoA Reductase-IN-1" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42445 | HMG-CoA Reductase-IN-1 | HMG-CoA Reductase |
| HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. | ||
| M2126 | Fluvastatin sodium | HMG-CoA Reductase |
| XU 62-320 | ||
| Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | ||
| M2846 | Mevastatin | Others |
| Compactin; ML236B | ||
| Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. | ||
| M21341 | β-Muricholic Acid | Metabolite/Endogenous Metabolite |
| β-Muricholic acid is a murine-specific primary bile acid. Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones. | ||
| M27634 | Simvastatin hydroxy acid sodium | HMG-CoA Reductase |
| Tenivastatin sodium; Simvastatin Impurity A sodium | ||
| Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M27949 | Simvastatin acid | HMG-CoA Reductase |
| Tenivastatin | ||
| Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin, is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28329 | Simvastatin acid ammonium | HMG-CoA Reductase |
| Tenivastatin ammonium | ||
| Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28423 | Cerivastatin sodium | HMG-CoA Reductase |
| Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. | ||
| M28490 | Cerivastatin | HMG-CoA Reductase |
| Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. | ||
| M28512 | Rosuvastatin Sodium | HMG-CoA Reductase |
| ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium | ||
| Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. | ||
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