About 10 results found for searched term "HL001" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21219 | Maralixibat chloride | Others |
| SHP625 chloride; LUM001 chloride; Lopixibat chloride | ||
| Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. (IBAT) is used in the study of rare cholestatic liver diseases, including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC), and biliary atresia. | ||
| M49409 | HL001 | LPL Receptor |
| HL001 is an LPA1 receptor antagonist that may be used in studies related to idiopathic pulmonary fibrosis (IPF). | ||
| M10288 | BMS-1001 | PD-1/PD-L1 |
| BMS-1001 free base; BMS1001 | ||
| Bms-1001 Hydrochloride is orally active and is an inhibitor of the human PD-L1/PD-1 immune checkpoint. Bms-1001 Hydrochloride is characterized by low cytotoxicity.r. | ||
| M10726 | ORY-1001 (trans) | Histone demethylase |
| ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride | ||
| Dihydrochloride, Iadademstat (ORY-1001) is an irreversible inhibitor of selective Lysine-specific demethylase 1A (KDM1A/LSD1). | ||
| M11043 | DJ001 | Others |
| DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor,IC50 is 1.43 μM. DJ001 has no inhibitory activity against other phosphatases and only moderate inhibitory activity against protein phosphatase 5. DJ001 Promotes hematopoietic stem cell regeneration. | ||
| M21437 | HET0016 | Cytochrome P450 (e.g. CYP17) |
| HET0016 is a highly efficient and selective inhibitor of 20-HETE synthase, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1, CYP4A2 and CYP4A3, respectively. HET0016 is a selective CYP450 inhibitor that has been shown to inhibit angiogenesis and tumor growth. | ||
| M29194 | Fosmanogepix | Antifungal |
| APX001; E1211 | ||
| Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl precursor which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections. | ||
| M29254 | BMS-1001 hydrochloride | PD-1/PD-L1 |
| BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells. | ||
| M30397 | VU10010 | AChR/AChE |
| VU10010 is a potent, highly selective and allosteric M4 mAChR potentiator with an EC50 of 400 nM. VU10010 binds to an allosteric site on M4 mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus. | ||
| M31059 | DPM-1001 trihydrochloride | Phosphatase |
| DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property. | ||
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