About 14 results found for searched term "HDAC8-IN-1" (0.168 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9098 | HDAC8-IN-1 | HDAC |
| ABM-7933; HDAC8 inhibitor 1 | ||
| HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. | ||
| M2101 | PCI-34051 | HDAC |
| PCI-34051 is a potent histone deacetylase (HDAC) 8 inhibitor with IC50 of 0.01 μM. | ||
| M5259 | Citarinostat | HDAC |
| ACY-241 | ||
| Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3. | ||
| M8594 | BRD3308 | HDAC |
| BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23 times more selective to HDAC3 than HDAC1 (IC50:1.26 μM) or HDAC2 (IC50:1.34 μM). BRD3308 inhibits pancreatic β cell apoptosis induced by inflammatory cytokines or glucolipid toxic stress and increases functional insulin release. BRD3308 also activates HIV-1 transcription and disrupts HIV-1 latency. | ||
| M8624 | HPB | Others |
| HPB is a cell-permeable, non-cytotoxic N-hydroxybenzamide derivative that acts as a HDAC6-selective deacetylase inhibitor (IC50 = 31/376/677/842/1133 nM against HDAC6/8/10/1/7, >2 μM against HDAC2/3/4/11/9/5). | ||
| M13671 | ACY-957 | HDAC |
| ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. | ||
| M13672 | AES-135 | HDAC |
| AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM. | ||
| M20644 | TH34 | HDAC |
| TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM). | ||
| M28352 | BRD6688 | HDAC |
| BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model. | ||
| M28849 | MC1742 | HDAC |
| MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC. | ||
| M30687 | BRD-6929 | HDAC |
| BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research. | ||
| M30884 | Tefinostat | HDAC |
| CHR-2845 | ||
| Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias. | ||
| M40605 | Snail/HDAC-IN-1 | HDAC |
| Snail/HDAC-IN-1 is a potent Snail/HDAC dual-targeting inhibitor with strong inhibitory activity against HDAC1 with an IC50 value of 0.405 μM, and against Snail with a Kd of 0.18 μM. In addition, Snail/HDAC-IN-1 also increases histone H4 acetylation and decreases Snail protein expression in HCT-116 cells, thereby inducing apoptosis. In addition, Snail/HDAC-IN-1 also increased histone H4 acetylation in HCT-116 cells and decreased Snail protein expression, thereby inducing apoptosis. | ||
| M45068 | Recombinant Human HDAC8 Protein (GST Tag) | Recombinant Proteins |
| Histone deacetylase 8 | ||
| Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. | ||
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