About 8 results found for searched term "Glutathione Peroxidase" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8380 | ML 210 | Others |
| Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines. | ||
| M9060 | RSL3 | Ferroptosis |
| 1S,3R-RSL3 | ||
| RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. | ||
| M10586 | JKE-1674 | Ferroptosis |
| JKE1674 | ||
| JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. | ||
| M10587 | ML162 | Ferroptosis |
| ML-162 | ||
| ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines. | ||
| M28749 | MitoEbselen-2 chloride | Apoptosis |
| MitoPeroxidase 2 | ||
| MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death. | ||
| M29297 | PKUMDL-LC-101-D04 | Glutathione Peroxidase |
| GPX4-Activator-1d4; PKU | ||
| PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. | ||
| M45203 | γ-Glu-Cys | Metabolite/Endogenous Metabolite |
| Gamma-glutamylcysteine | ||
| γ-Glu-Cys is a dipeptide containing cysteine and glutamate, and is also a precursor of glutathione (GSH). In addition, γ-Glu-Cys is a cofactor in the increase of GSH levels by glutathione peroxidase (GPx). | ||
| M49462 | GPX4-IN-3 | Ferroptosis |
| GPX4-IN-3 is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis.1 μM of GPX4-IN-3 inhibited 71.7% of GPX4 activity. | ||
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