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 About 1 result found for searched term "GSK2193874" (0.117 seconds)

Cat.No.  Name Target
M10625 GSK2193874 TRP Channel
GSK-2193874; GSK2193874A
GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.



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