About 13 results found for searched term "GSK-3β inhibitor 2" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49757 | GSK-3β inhibitor 2 | GSK-3 |
| GSK-3β inhibitor 2 is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. | ||
| M2354 | 1-Azakenpaullone | GSK-3 |
| 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. | ||
| M2405 | AR-A014418 | GSK-3 |
| GSK-3β Inhibitor VIII | ||
| AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM, without significant inhibition on 26 other kinases tested. | ||
| M3054 | TDZD-8 | GSK-3 |
| GSK-3β Inhibitor I; NP 01139 | ||
| TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. | ||
| M5538 | Cromolyn sodium | GSK-3 |
| Disodium Cromoglycate | ||
| Cromolyn sodium is an antiallergic compound. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM. | ||
| M10108 | Indirubin-3'-monoxime | GSK-3 |
| I3MO | ||
| Indirubin-3'-monoxime is a potent GSK-3β inhibitor with IC50 of 22 nM, and inhibits Cdk5/p35, Cdk1/cyclin-B and Cdk2/cyclin-E with IC50s of 100, 180, 250 nM. | ||
| M10531 | BRD3731 | GSK-3 |
| BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. | ||
| M28650 | BRD0209 | GSK-3 |
| BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases. | ||
| M29819 | ZLWH-23 | AChR/AChE |
| ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease. | ||
| M49734 | AChE/GSK-3β-IN-1 | AChR/AChE |
| AChE/GSK-3β-IN-1 is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. | ||
| M49750 | 5-Iodo-indirubin-3'-monoxime | GSK-3 |
| 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. | ||
| M49759 | GSK-3β inhibitor 6 | GSK-3 |
| GSK-3β inhibitor 6 is a potent GSK-3β inhibitor with an IC50 value of 24.4 μM. | ||
| M49760 | GSK-3β inhibitor 7 | GSK-3 |
| GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. | ||
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