GPX4-IN-5 - Search Results | AbMole BioScience

About 5 results found for searched term "GPX4-IN-5" (0.119 seconds)

Cat.No.	Name	Target
M42429	GPX4-IN-5	Glutathione Peroxidase
	GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM.
M8380	ML 210	Others
	Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines.
M29297	PKUMDL-LC-101-D04	Glutathione Peroxidase
	GPX4-Activator-1d4; PKU
	PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts.
M42430	GPX4-IN-6	Glutathione Peroxidase
	GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.
M43932	N6F11	Ferroptosis
	2-(chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
	N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.