About 12 results found for searched term "FGFR4-IN-1" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8936 | FGFR4-IN-1 | FGFR |
| FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with IC50 of 0.7 nM. | ||
| M43503 | FGFR4-IN-16 | FGFR |
| FGFR4-IN-16 (CY-15-2) is a covalent inhibitor of FGFR-4 for cancer research. | ||
| M43508 | FGFR4-IN-14 | FGFR |
| FGFR4-IN-14 is a FGFR4 inhibitor (IC50: 2.4 nM. | ||
| M5237 | Fisogatinib | FGFR |
| BLU554 | ||
| Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM. | ||
| M5242 | H3B-6527 | FGFR |
| H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice. | ||
| M5253 | BLU-9931 | FGFR |
| BLU9931 | ||
| BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively. | ||
| M9596 | Pemigatinib | FGFR |
| INCB054828 | ||
| Pemigatinib (INCB054828) is an orally effective, selective FGFR inhibitor with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Pemigatinib exhibited anti-tumor activity in mouse xenograft models with FGFR1, FGFR2, or FGFR3-altered human tumors in a mouse xenograft model exhibiting antitumor activity. | ||
| M10026 | Futibatinib (TAS-120) | FGFR |
| TAS-120 | ||
| Futibatinib (TAS-120) is an oral bioavailable, highly selective and irreversible FGFR inhibitor with IC50 of 3.9, 1.3, 1.6 and 8.3 nM against the four FGFR 1-4 subtypes, respectively. Futibatinib inhibited mutant and wild-type FGFR2 with IC50 similarity (wild-type FGFR2=0.9 nM; V5651 = 1 to 3 nM; N550H = 3.6 nM. E566G = 2.4 nM). | ||
| M10737 | PRN1371 | FGFR |
| PRN1371 is a highly selective and potent inhibitor of FGFR1-4 and CSF1R against FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R IC50 The values are 0.6, 1.3, 4.1, 19.3, and 8.1 nM, respectively. | ||
| M28061 | FIIN-1 | FGFR |
| FGFR irreversible inhibitor-1 | ||
| FIIN-1 is a potent, irreversible, selective FGFR inhibitor. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC50s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively. | ||
| M28863 | PD-089828 | FGFR |
| PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity. | ||
| M54696 | DGY-09-192 | PROTAC |
| DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. | ||
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