About 7 results found for searched term "Eukaryotic Initiation Factor" (0.149 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10086 | 2-Aminopurine | Nucleic Acid Staining |
| 2-AP | ||
| 2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes. 2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. 2-Aminopurine has been used to probe nucleic acid structure and dynamics. | ||
| M13660 | eIF4A3-IN-1 | Others |
| eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. | ||
| M13664 | Silvestrol | Others |
| (-)-Silvestrol | ||
| Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from the fruits and twigs of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis. | ||
| M20585 | Briciclib | Others |
| ON-014185 | ||
| Briciclib is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E) . | ||
| M29296 | 2BAct | Eukaryotic Initiation Factor |
| 2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB. | ||
| M29546 | CMLD012612 | Eukaryotic Initiation Factor |
| CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity. | ||
| M55982 | DNL343 | Eukaryotic Initiation Factor |
| DNL343 is an orally active, brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). | ||
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