About 8 results found for searched term "ESI-05" (0.132 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8728 | ESI-05 | Transferase |
| NSC 116966 | ||
| Esi-05 (NSC 116966) is a camp-specific direct activated exchange protein 2 (EPAC2) antagonist with an IC50 value of 0.4 µM that inhibits camp-induced EPAC2 activation and EAPC2-mediated Rap1 activation. | ||
| M5043 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response. | ||
| M27751 | PK14105 | Others |
| PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors. in vivo binding experiments, in which PK 14105 was injected into rats with unilaterally lesioned striata, demonstrate that PK 14105 rapidly crosses the blood-brain-barrier and that there is a marked retention of radioactivity in the lesioned striatum not seen in the unlesioned striatum or cerebellar vermis. It can also inhibit receptor ligands, calcium channel ligands and co-transporter in all salivary glands. | ||
| M30099 | (rac)-AG-205 | NF-κB |
| (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway. | ||
| M43927 | SGR-1505 | MALT1 |
| SGR1505 | ||
| SGR-1505 is an oral potent small molecule allosteric inhibitor of MALT1 that inhibits MALT1 enzymatic activity and demonstrates anti-proliferative activity in ABC-DLBCL cell lines, both BTKi-sensitive (OCI-LY10) and BTKi-resistant (OCI-LY3). SGR-1505 can be used in studies related to B-cell tumors. | ||
| M53446 | CEF8, Influenza Virus NP (383-391) | Anti-infection |
| CEF8, Influenza Virus NP (383-391), an influenza A virus nucleoprotein containing residues 383 to 391, is the most important HLA-B*2705-restricted epitope in the nucleoprotein of influenza A viruses. | ||
| M54031 | HSV-gB2 (498-505) | Anti-infection |
| HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope. | ||
| M58500 | EverFluor Fl C5-Ceramide | Fluorescent Dye |
| BODIPY FL C5-Ceramide | ||
| BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em= 505 nm/512 nm | ||
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