About 24 results found for searched term "ES9-17" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M22300 | ES9-17 | Others |
| ES9-17 | ||
| M1826 | Sunitinib Malate | VEGFR/PDGFR |
| SU-11248, Sutent | ||
| Sunitinib is a multitargeted tyrosine kinase inhibitor of VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively. | ||
| M2593 | Siramesine hydrochloride | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. | ||
| M2592 | Siramesine | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. | ||
| M1596 | Apigenin 7-O-glucuronide | MMP |
| Apigenin-7-glucuronide | ||
| Apigenin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. | ||
| M4058 | 11-oxo-mogroside-V | ROS |
| 11-Oxo-Mogroside V is a natural sweetener with strong antioxidant activity. 11-OXo-Mogroside V had a significant inhibitory effect on reactive oxygen species, and the EC50 of O2-, H2O2 and *OH were 4.79, 16.52 and 146.17 μg/mL, respectively. | ||
| M5065 | Cebranopadol | Opioid Receptor |
| GRT-6005 | ||
| Cebranopadol is a NOP and opioid receptor agonist that acts on human NOP, MOP, KOP and δ-opioid peptide (DOP) receptors with Ki/EC50 values of 0.9 nM/13 nM and 0.7 nM/1.2 nM, respectively. 2.6 nM/17 nM, 18 nM/110 nM. | ||
| M5066 | N-Desethyl Sunitinib | Metabolite/Endogenous Metabolite |
| SU11662 | ||
| N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). | ||
| M5114 | Calcein-AM | Fluorescent Dye |
| Calcein acetoxymethyl ester | ||
| Calcein-am is a fluorescent dye that penetrates cells and is used to measure cell viability. The excitation and emission wavelengths of Calcein are 494 nm and 517 nm, respectively. Fluorescent green. Store at -20℃ away from light. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M8773 | Liarozole dihydrochloride | Others |
| Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) that targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyas |
||
| M10923 | Giredestrant | Estrogen Receptor |
| GDC-9545; RG6171 | ||
| Giredestrant (GDC-9545, RG6171) is an orally active, selective estrogen receptor degrader (SERD) with best-in-class potential to compete with estradiol in the ER ligand binding domain and induce conformational changes.Giredestrant has antitumor activity. | ||
| M13760 | 5(6)-CFDA | Cell Staining |
| 5-(6)-Carboxyfluorescein diacetate; CFDA | ||
| 5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) is a cell-permeant, amine-reactive green fluorescent probe used to stain cells for analysis in applications. (λex: 492 nm; λem: 517 nm). | ||
| M15017 | Recombinant Human TGFBR2 (Mammalian,C-Fc) | Recombinant Proteins |
| TGF-beta type II receptor | ||
| Recombinant human TGFBR2 protein (C-FC) is generated by Mammalian expression system, and the target gene encoding Thr23-ASP159 is expressed at the C-terminal with Fc label. Accession # : P37173. | ||
| M14633 | Isocurcumenol | Estrogen Receptor |
| Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively. | ||
| M21084 | GA-017 | YAP |
| GA-017 is a potent and selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2) with IC50 values of 4.10 and 3.92 nM, respectively.GA-017 is a cell proliferation activator.GA-017 promotes YAP/TAZ activation and nuclear translocation.GA-017 promotes cell growth in 3D culture conditions.GA-017 Enhances the formation of mouse intestinal organoid isolates. | ||
| M21677 | Recombinant Human Follistatin 288 (Mammalian, C-6His) | Recombinant Proteins |
| FST; follistatin isoform FST317 | ||
| Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Recombinant Human Follistatin/FST is produced by Mammalian expression system and the target gene encoding Gly30-Asn317 is expressed with a 6His tag at the C-terminus. | ||
| M21705 | Recombinant Mouse IL-17F (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-17F | ||
| Recombinant Mouse Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. | ||
| M22451 | Recombinant Human ApoE (Mammalian, C-6His) | Recombinant Proteins |
| Apolipoprotein E; Apo-E | ||
| Recombinant Human Apolipoprotein E is produced by Mammalian expression system and the target gene encoding Lys19-His317 is expressed with a 6His tag at the C-terminus. ApoE is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. | ||
| M22527 | Cinchonidine | Alkaloids |
| α-Quinidine | ||
| Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. | ||
| M28502 | JG26 | MMP |
| JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively. | ||
| M29507 | ERD-308 | PROTAC |
| ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively). | ||
| M31361 | Recombinant Human MRAP Protein (HEK293, hFc Tag) | Recombinant Proteins |
| Melanocortin 2 Receptor Accessory Protein; FALP; B27 | ||
| MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. A DNA sequence encoding the human MRAP (Tyr59-Ser172) was expressed with the Fc region of human IgG1 at the N-terminus. | ||
| M45365 | Lobatoside C | Others |
| Lobatoside C, a triterpenoid saponin isolated from hyoscyamus with arabinose terminal sugar, inhibited SW-620, SK-MEL-5, and UO-31 cell lines with GI50 values of 8.91, 4.17, and 6.03, respectively. | ||
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